|
KMID : 0385020020180010028
|
|
Korean Journal of Laboratory Animal Science
2002 Volume.18 No. 1 p.28 ~ p.31
|
|
|
Significance of Dextromethorphan Molecule for Anticonvulsant Effect-Metabolizing Process is Not Necessary for Dextromethorphan´s Anticonvulsant Effect
|
|
Choi, Shin Geon
Im, Doo Hyun/Kim, Hyoung Chun/Shin, Eun Joo/Kang, Kee Seok/Lee, Phil Ho/Oh, Kyung Sook
|
|
|
Abstract
|
|
|
|
The effects of dextromethorphan (DM), and its metabolites (dextrorphan, 3-hydroxymorphinan and 3-methoxymorphinan) on kainic acid-induced seizures in mice and rats were examined. Intracerebroventricular injection with dextromethorphan or dextrorphan (5 or 10㎍ / 0.5μl/mouse) significantly attenuated seizures induced by kainic acid (0.07㎍/0.07μl) in a dose-related manner. Dextromethorphan appears to be a more potent neuroprotectant than dextrorphan. In contrast, 3-hydroxymorphinan or 3-methoxymorphinan had no effect on kainic acid-induced seizures. These findings were consistently observed in the rat case. Combined, our results suggest that metabolism of DM to dextrorphan, 3-hydroxymorphinan or 3-methoxymorphinan is not essential for dextromethorphan to exert its anticonvulsant effect.
|
|
|
KEYWORD
|
|
|
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|
|